AUTHOR=Masarone Daniele , Petraio Andrea , Fiorentino Antonio , Dellegrottaglie Santo , Valente Fabio , Ammendola Ernesto , Nigro Gerardo , Pacileo Giuseppe 

TITLE=Use of Cardiac Contractility Modulation as Bridge to Transplant in an Obese Patient With Advanced Heart Failure: A Case Report

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.833143

DOI=10.3389/fcvm.2022.833143

ISSN=2297-055X

ABSTRACT=Cardiac contractility modulation (CCM) is a novel device-based therapeutic approach in patients with heart failure with reduced ejection fraction (HFrEF). In randomized clinical trials and observational studies, CCM has been shown to result in improved exercise tolerance, improved quality of life, reverse left ventricular remodelling and reduced hospitalization in patients with HFrEF. 
In this case report, we describe for the first time the use of CCM as a “bridge to transplant” in a young obese patient with non-ischemic dilated cardiomyopathy with frequent hospitalizations for heart failure. The patient had a poor quality of life and frequent heart failure-related hospitalizations despite optimal medical therapy and, due to obesity, a suitable heart donor was unlikely to be identified in the short term and due to severe obesity risk of complications after implantation of a left ventricular assist device (LVAD) was very high.