AUTHOR=Bai Yaya , Wang Qian , Cheng Di , Hu Yueliang , Chao Huijuan , Avolio Alberto , Tang Biwen , Zuo Junli 

TITLE=Comparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.839875

DOI=10.3389/fcvm.2022.839875

ISSN=2297-055X

ABSTRACT=Objectives: The aim of this study was to explore the risk of target organ damage (TOD) in different groups based on carotid-femoral pulse wave velocity (cfPWV) and central aortic blood pressure (CBP) in different populations.
Methods: The study cohort was divided into four groups according to the status of cfPWV and CBP [Group(cfPWV/CBP): high cfPWV and high CBP; Group(cfPWV): high cfPWV and normal CBP; Group(CBP): normal cfPWV and high CBP; Group(control) : normal cfPWV and normal CBP). TOD was determined by assessment of carotid intima-media thickness (CIMT) abnormality, chronic kidney disease (CKD), microalbuminuria, and left ventricular hypertrophy (LVH).
Results:1280 patients (mean age 53.14±12.76 years, 64.1% males) were recruited in this study. Regarding Group(control)  as reference, LVH was significantly higher in Group(cfPWV) and Group(CBP) [OR 2.406，95% CI(1.301-4.452), P＜0.05; OR 2.007，95% CI (1.335-3.017), P＜0.05] ; microalbuminuria was significantly higher in Group(cfPWV/CBP) and Group(CBP) [OR 3.219，95% CI (1.630-6.359), P＜0.05；OR 3.156，95% CI (1.961-5.079), P＜0.05].  With age stratified by 60 years, the risk of CKD was significantly higher in Group(cfPWV/CBP) [OR 4.019，95% CI (1.439-11.229),  P＜0.05].
Conclusions: Different phenotypes based on the status of cfPWV and CBP were associated with different TOD. Individuals with both cf-PWV and CBP elevated have a higher risk of microalbuminuria.