AUTHOR=Anselmino Matteo , Scarsoglio Stefania , Ridolfi Luca , De Ferrari Gaetano Maria , Saglietto Andrea 

TITLE=Insights from computational modeling on the potential hemodynamic effects of sinus rhythm versus atrial fibrillation

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.844275

DOI=10.3389/fcvm.2022.844275

ISSN=2297-055X

ABSTRACT=Atrial fibrillation (AF) is the most common clinical tachyarrhythmia, posing significant burden to patients, physicians and healthcare systems worldwide. With the advent of more effective rhythm control strategies, such as AF catheter ablation, an early rhythm control strategy is progressively demonstrating its superiority not only in symptoms control, but also in prognostic terms, over a standard strategy (rate control, with rhythm control reserved only to patients with refractory symptoms).
This review summarizes the different impact exerted by AF on heart mechanics and systemic circulation, as well as on cerebral and coronary vascular beds, providing computational modeling-based hemodynamic insights in favour of pursuing sinus rhythm maintenance in AF patients.