AUTHOR=Vallée Alexandre 

TITLE=Association Between Lipids and Arterial Stiffness for Primary Cardiovascular Prevention in a General Middle-Aged European Population

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.899841

DOI=10.3389/fcvm.2022.899841

ISSN=2297-055X

ABSTRACT=Background: Dyslipidemia contributes to the progression of arterial stiffness (AS). The purpose of this study was to investigate the association of the different lipid parameters with arterial stiffness index (ASI) in a middle-aged population free from cardiovascular (CV) disease. 
Methods: Among 71,326 volunteers of the UK Biobank population, Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), Lipoprotein(a), Apolipoproteins A and B and ASI were measured. Values for non-HDL, TC/HDL, TG/HDL, LDL/HDL were calculated. AS was defined as ASI>10m/s. Associations between lipid parameters and ASI were performed by multiple linear logistic regressions. Results reported from univariate models were the squared partial correlation coefficient, r2, and from multivariate models, the adjusted coefficient of determination, R2, to describe the contribution of ASI variability for each lipid parameter. 
Results: We found that TG/HDL was mainly associated with ASI (Beta=0.53 (0.01), r2=3.66%, p<0.001and adjusted Beta=0.21 (0.01), R2=13.58%, p<0.001) and AS (OR=1.86 [1.80 – 1.92], r2=1.65%, p<0.001 and adjusted OR=1.15 [1.13-1.17], R2=8.54%, p<0.001) rather than the others. TG/HDL remained the only lipid parameter showing an added value in linear multivariate models. TG/HDL remained less associated with arterial stiffness than age (r2=5.55%, p<0.001), mean BP (r2=5.31%, p<0.001), and gender (r2=4.44%, p<0.001), but more highly associated than BMI (r2=1.95%, p<0.001),  heart rate (r2=0.81%, p<0.001), fasting glucose (r2=0.18%, p<0.001), tobacco (r2=0.05%, p<0.001) and GFR (r2=0.01%, p<0.001). 
Conclusions: In primary CV prevention, lipids, especially through the ratio TG/HDL, could be more instructive to target to prevent the increase in AS than other modifiable factors.