AUTHOR=Wu Yun-Yun , Shan Su-Kang , Lin Xiao , Xu Feng , Zhong Jia-Yu , Wu Feng , Duan Jia-Yue , Guo Bei , Li Fu-Xing-Zi , Wang Yi , Zheng Ming-Hui , Xu Qiu-Shuang , Lei Li-Min , Ou-Yang Wen-Lu , Tang Ke-Xin , Li Chang-Chun , Ullah Muhammad Hasnain Ehsan , Yuan Ling-Qing 

TITLE=Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.912358

DOI=10.3389/fcvm.2022.912358

ISSN=2297-055X

ABSTRACT=Vascular calcification is prevalent in ageing, diabetes, chronic kidney disease, cardiovascular disease, and certain genetic disorders. However, the pathogenesis of vascular calcification is not well understood. It has been gradually recognised that vascular calcification depends on the bidirectional interactions between vascular cells and their environment. Exosomes are essential bridges to mediate crosstalk between cells and organisms, and thus they have attracted increased research attention in recent years. Accumulating evidence has indicated that exosomes play an important role in cardiovascular disease, especially in vascular calcification. In this review, we introduce vascular biology and focus on the crosstalk between the different vessel layers and how their interplay controls the process of vascular calcification.