AUTHOR=Frumkin David , Pietron Malte , Kind Andreas , Brand Anna , Knebel Fabian , Laule Michael , Leistner David M. , Landmesser Ulf , Krackhardt Florian , Sherif Mohammad , Sündermann Simon H. , Grubitzsch Herko , Lembcke Alexander , Niehues Stefan M. , Stangl Karl , Dreger Henryk 

TITLE=Valve embolization during transcatheter aortic valve implantation: Incidence, risk factors and follow-up by computed tomography

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.928740

DOI=10.3389/fcvm.2022.928740

ISSN=2297-055X

ABSTRACT=Background: In most cases of transcatheter valve embolization and migration (TVEM), the embolized valve remains in the aorta after implantation of a second valve into the aortic root. There is little data on potential late complications such as valve thrombosis or aortic wall alterations by embolized valves. 
Aims: The aim of this study was to analyze the incidence of TVEM in a large cohort of patients undergoing transcatheter aortic valve implantation (TAVI) and to examine embolized valves by computed tomography (CT) late after TAVI. 
Methods: The patient database of our center was screened for cases of TVEM between July 2009 and July 2021. To identify risk factors, TVEM cases were compared to a cohort of 200 consecutive TAVI cases. Out of 35 surviving TVEM patients, ten patients underwent follow-up by echocardiography and CT. 
Results: 54 TVEM occurred in 3757 TAVI procedures, 46 cases were managed percutaneously. Horizontal aorta (odds ratio [OR] 7.51, 95% confidence interval [CI] 3.4-16.6, p < 0.001), implantation of a self-expanding valve (OR 4.63, 95% CI 2.2-9.7, p < 0.01) and a left ventricular ejection fraction <40% (OR 2.94, 95% CI 1.1-7.3, p = 0.016) were identified as risk factors for TVEM. CT scans were performed on average 26.3 months after TAVI (range 2-84 months) and detected hypoattenuated leaflet thickening (HALT) in two patients as well as parts of the stent frame protruding into the aortic wall in three patients.
Conclusions: TVEM represents a rare complication of TAVI. Follow up-CT detected no pathological findings requiring intervention.