AUTHOR=Lei Xinjun , Liang Qi , Fang Yuan , Xiao Yihui , Wang Dongqi , Dong Maozhi , Li Jiancheng , Yu Ting TITLE=Guidezilla™ guide extension catheter I for transradial coronary intervention JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 9 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.931373 DOI=10.3389/fcvm.2022.931373 ISSN=2297-055X ABSTRACT=Background: Percutaneous coronary intervention (PCI) is the preferred treatment method for coronary artery diseases (CAD). This study aimed to evaluate the effectiveness and complications of the GuidezillaTM guide extension catheter (GGEC) in transradial coronary intervention (TRI). Methods: This case series study included patients with CAD who underwent TRI using the GGEC between August 2016 and January 2019 at the First Affiliated Hospital of Xi’an Jiaotong University. Results: A total of 221 patients with a mean age of 65.1 ± 9.26 years were included. Coronary angiography results indicated that most patients (77.8%) had triple-vessel lesions, of which 47.5% had chronic total occlusion (CTO). A total of 237 target lesions were treated, most being type C lesions (95.8%). The most common indication for GGEC use was heavy calcification (67%), followed by extreme tortuosity (12.2%), extreme tortuosity and heavy calcification (10.9%), distally located lesion (4.5%), picking up the retrograde wire (3.2%), anomalous vessel origin (1.8%), and releasing the burr incarceration (0.4%). The mean operation time was 58 min, and the overall success rate was 94.1%. Four patients received a drug-coated balloon. No significant difference was found in operation time and success rate among the low (<23), intermediate (23-32), and severe (>32) CAD groups based on SYNTAX score stratification (P > 0.05). Two cases of subacute thrombosis were reported perioperatively, during hospitalization, and at the 1-month follow-up. Conclusion: The GGEC might have advantages for TRI and is unaffected by SYNTAX score stratification.