AUTHOR=Wang Heng , He Yi , Fan Jia-Li , Li Xu , Zhou Bing-Yuan , Jiang Ting-Bo , He Yong-Ming 

TITLE=The predictive value of CatLet© angiographic scoring system for long-term prognosis in patients with acute myocardial infarction presenting > 12 h after symptom onset

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.943229

DOI=10.3389/fcvm.2022.943229

ISSN=2297-055X

ABSTRACT=Abstract: Background: We have recently developed the Coronary Artery Tree description and Lesion EvaluaTion (CatLet©) angiographic scoring system, which is capable to account for the variability in coronary anatomy, and to risk-stratify patients with coronary artery disease. This study aimed to clarify whether the CatLet score had a predictive value for long-term prognosis in patients with acute myocardial infarction (AMI) presenting >12 h after symptom onset. Methods: The CatLet score was calculated in 1018 consecutively enrolled AMI patients, who were divided into 3 groups according to the CatLet score tertiles. Primary endpoint was major adverse cardiac events (MACEs), defined as a composite of myocardial infarction, cardiac death, and ischemia-driven revascularization; secondary endpoints were all-cause death, cardiac death, myocardial infarction, and ischemia-driven revascularization. Results: The CatLet score was capable of predicting long-term prognosis at a median 4.9-year follow-up alone or after adjustment for risk factors. Multivariable-adjusted hazard ratios (95%CI) / unit higher score were 1.06 (1.05-1.08) for MACEs, 1.05 (1.03-1.07) for all-cause death, 1.06 (1.04-1.09) for cardiac death, 1.06 (1.04-1.08) for myocardial infarction, and 1.06 (1.04-1.08) for revascularization. The univariate model showed a good calibration (χ2= 8.25, P= 0.4091) and a good discrimination (Area under ROC curve= 0.7086) for MACEs. Conclusions: The CatLet score is an independent predictor of long-term clinical outcomes of patients with AMI presenting >12 hour after symptom onset. (http://www.chictr.org.cn; Registry Number: ChiCTR2000033730)