AUTHOR=Fan Xiaoyan , Zhang Zhenwei , Zheng Liang , Wei Wei , Chen Zetao 

TITLE=Long non-coding RNAs in the pathogenesis of heart failure: A literature review

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.950284

DOI=10.3389/fcvm.2022.950284

ISSN=2297-055X

ABSTRACT=Heart failure (HF) is a common cardiovascular disorder and a major cause of mortality, and morbidity in older people. The mechanism is still not fully understood and may halt the drug development of HF, especially HF with preserved ejection fraction. Besides, few drug has been shown to improve the survival of the HF patients. Increasing evidences suggest that long noncoding RNAs (lncRNAs) serve as a critical regulator of cardiac physiological and pathological processes, regarded as a new target of treatment for HF. LncRNAs are versatile players in the pathogenesis of HF. They can interact with chromatin, protein, RNA or DNA thereby modulating chromatin accessibility, gene expressions and signaling transduction. In this review, we summarized current knowledge on how lncRNAs involve in HF, and categorized into four pattens based on their biological functions, including cardiomyocyte contractility, cardiac hypertrophy, cardiac apoptosis and myocardial fibrosis. Along with the extensive laboratory data, RNA-based therapeutics achieved great advances recent years. These indicate that targeting lncRNAs in the treatment of HF may provide new strategies and address the unmet clinical needs.