AUTHOR=Polimeni Alberto , Spaccarotella Carmen , Ielapi Jessica , Esposito Giovanni , Ravera Amelia , Martuscelli Eugenio , Ciconte Vincenzo , Menichelli Maurizio , Varbella Ferdinando , Imazio Massimo , Navazio Alessandro , Sinagra Gianfranco , Oberhollenzer Rainer , Sibilio Gerolamo , Cacciavillani Luisa , Meloni Luigi , Dominici Marcello , Tomai Fabrizio , Amico Francesco , Corda Marco , Musumeci Giuseppe , Lupi Alessandro , Zezza Luigi , De Caterina Raffaele , Cernetti Carlo , Metra Marco , Rossi Lidia , Calabrò Paolo , Murrone Adriano , Volpe Massimo , Caldarola Pasquale , Carugo Stefano , Cortese Bernardo , Valenti Renato , Boriani Giuseppe , Fedele Francesco , Ventura Giorgio , Manes Maria Teresa , Colavita Angela Rita , Feola Mauro , Versaci Francesco , Assennato Pasquale , Arena Giuseppe , Ceravolo Roberto , Amodeo Vincenzo , Tortorici Gianfranco , Nassiacos Daniele , Antonicelli Roberto , Esposito Nicolino , Favale Stefano , Licciardello Giovanni , Tedesco Luigi , Indolfi Ciro 

TITLE=The impact of UEFA Euro 2020 football championship on Takotsubo Syndrome: Results of a multicenter national registry

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.951882

DOI=10.3389/fcvm.2022.951882

ISSN=2297-055X

ABSTRACT=Objectives: 
The UEFA 2020 European Football Championship held in multiple cities across Europe from June 11 to July 11, 2021, was won by Italy, providing an opportunity to examine the relationship between emotional stress and the incidence of acute cardiovascular events (ACE).
Methods and Results
Cardiovascular hospitalizations in the Cardiac Care Units of 49 hospital networks in Italy were assessed by emergency physicians during the UEFA Euro 2020 Football Championship. We compared the events that occurred during matches involving Italy with events that occurred during the remaining days of the championship as the control period.
ACE were assessed in 1235 patients. ACE during the UEFA Euro 2020 Football Championship semifinal and final, the most stressful matches ended with penalties and victory of the Italian team, were assessed.  
A significant increase in the incidence of Takotsubo Syndrome (TTS) by a factor of 11.41 (1.6 - 495.1, P<0.003), as compared with the control period, was demonstrated during the semifinal and final, whereas no differences were found in the incidence of ACS [IRR 0.93(0.74-1.18), P=0.57]. 
No differences in the incidence of ACS [IRR 0.98 (0.87-1.11; P=0.80)] or TTS [IRR 1.66(0.80-3.4), P=0.14] were found in the entire period including all matches of the UEFA Euro 2020 compared to the control period. 
Conclusions: 
The data of this national registry demonstrated an association between the semifinal and final of UEFA Euro 2020 and TTS suggesting that it can be triggered by also positive emotions as the victory of the European Football Championship finals.