AUTHOR=Yang Lin , Liu Jianlin , Liu Chao TITLE=Case report: Unusual persistent hypotension and acute occlusion after peripheral paclitaxel balloon angioplasty JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 9 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.964601 DOI=10.3389/fcvm.2022.964601 ISSN=2297-055X ABSTRACT=Background: Paclitaxel-coated balloon (PCB) angioplasty is a mainstream treatment for peripheral artery disease; however, the safety of PCB remains controversial. Case presentation: We confirmed acute occlusion during PCB angioplasty in a patient with femoropopliteal artery occlusion. The occluded vessels were revascularized completely after endovascular medical therapy and bailout stenting angioplasty. Then, the patient experienced persistent postprocedure orthostatic hypotension (30 days) and received hydration and vasoactive agents with a target mean arterial blood pressure of 75 to 85 mmHg. The patient’s blood pressure gradually recovered over the 30 days after the procedure, and there was no recurrence of symptomatic hypotension during the follow-up. Conclusions: This rare complication is helpful to evaluate the safety of the PCB device.