AUTHOR=Kim Ju Hyeon , Franchin Luca , Hong Soon Jun , Cha Jung-Joon , Lim Subin , Joo Hyung Joon , Park Jae Hyoung , Yu Cheol Woong , Lim Do-Sun , De Filippo Ovidio , Gwon Hyeon-Cheol , Piroli Francesco , Kim Hyo-Soo , Wanha Wojciech , Choi Ki Hong , Song Young Bin , Patti Giuseppe , Nam Chang-Wook , Bruno Francesco , Kang Jeehoon , Bocchino Pier Paolo , De Ferrari Gaetano Maria , Koo Bon-Kwon , D’Ascenzo Fabrizio 

TITLE=Two-Year clinical outcomes after coronary bifurcation stenting in older patients from Korea and Italy

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1106594

DOI=10.3389/fcvm.2023.1106594

ISSN=2297-055X

ABSTRACT=Background: Older patients who treated by percutaneous coronary intervention (PCI) are at a higher risk of adverse cardiac outcomes. We sought to investigate the clinical impact of bifurcation PCI in older patients from Korea and Italy.
Methods: We selected 5,537 patients who underwent bifurcation PCI from the BIFURCAT (comBined Insights from the Unified RAIN and COBIS bifurcAtion regisTries) database. The primary outcome was a composite of target vessel myocardial infarction, clinically driven target lesion revascularization, and stent thrombosis at two years. 
Results: In patients aged ≥75 years, the mean age was 80.1 ± 4.0 years, 65.2% were men, and 33.7% had diabetes. Older patients more frequently presented with chronic kidney disease (CKD), severe coronary calcification, and left main coronary artery disease (LMCA). During a median follow-up of 2.1 years, older patients showed similar adverse clinical outcomes compared to younger patients (the primary outcome, 5.7% vs. 4.5%; p = 0.21). Advanced age was not an independent predictor of the primary outcome (p = 0.93) in overall patients. Both CKD and LMCA were independent predictors regardless of age group. 
Conclusions: Older patients (≥75 years) showed similar clinical outcomes to those of younger patients after bifurcation PCI. Advanced age alone should not deter physicians from performing complex PCIs for bifurcation disease.