AUTHOR=Leng Yurong , Hu Qinwen , Ling Qin , Yao Xiongda , Liu Menglu , Chen Jiawei , Yan Zhiwei , Dai Qun 

TITLE=Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1114927

DOI=10.3389/fcvm.2023.1114927

ISSN=2297-055X

ABSTRACT=Objectives: Studies have established a link between periodontal disease and cardiovascular disease (CVD), but. There is a lack of meta analyzing sex difference in the association between periodontal diseases and CVD.
Methods: The PubMed, Embase and Cochrane databases were searched until June, 21 2022. Cardiovascular outcomes included any CVD, myocardial infarction (MI), coronary heart disease (CHD) or stroke. Studies comparing the incidence of CVD in patients with periodontal disease and periodontal disease were included.
Results: Twenty-six studies were included. Among patients with periodontal disease, the prevalence of CVD was 7.2% (9 studies; 95% confidence interval (CI): 2.7% to 13.6%), and prevalence for CHD, hypertension, stroke and heart failure was 6.6%, 25.3%, 1% and 1.1%, respectively. There was a significant association between periodontal disease and CVD in men (odds ratio (OR) = 1.22; 95% CI:1.12-1.34) and women (OR = 1.11; 95% CI:1.05-1.17), with no significant sex difference (P >0.05).
Conclusion: CVD is relatively common in patients with periodontal disease, and an increased risk of CVD is associated with periodontal disease independent of sex. Interventions targeting periodontal disease may be beneficial for CVD.