AUTHOR=Mao Zhi-Jie , Wen Wei-Wei , Han Yi-Chen , Dong Wei-hua , Shen Li-juan , Huang Zhou-Qing , Xie Qiang-Li 

TITLE=Use of the cardiopulmonary coupling index based on refined composite multiscale entropy for prognostication of acute type A aortic dissection

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1126889

DOI=10.3389/fcvm.2023.1126889

ISSN=2297-055X

ABSTRACT=Objectives
The aim of this study is to assess the influence of cardiopulmonary coupling (CPC) based on RCMSE on the prediction of complications and death in patients with acute type A aortic  dissection (ATAAD).
Background
The cardiopulmonary system may be nonlinearly regulated, and its coupling relationship with postoperative risk stratification in ATAAD patients has not been studied.
Methods
This study was a single-center, prospective cohort study (ChiCTR1800018319). We enrolled 39 patients with ATAAD. The outcomes were in‐hospital complications and all-cause readmission or death at 2 years.
Results
Of the 39 participants, 16 (41.0%) developed complications in the hospital, and 15 (38.5%) died or were readmitted to the hospital during the two-year follow-up. When CPC-RCMSEwas used to predict in‐hospital complications in ATAAD patients, the AUC was 0.853(p<0.001). When CPC-RCMSE was used to predict all-cause readmission or death at 2 years, 
the AUC was 0.731 (p<0.05). After adjusting for age, sex, ventilator support (days), and specialcare time (days), CPC-RCMSE remained an independent predictor of in‐hospital complications in patients with ATAAD (adjusted OR 0.8 (95% CI, 0.68–0.94)).
Conclusion
CPC-RCMSE was an independent predictor of in‐hospital complications and all-cause readmission or death in patients with ATAAD.