AUTHOR=Zdanyte Monika , Borst Oliver , Münzer Patrick 

TITLE=NET-(works) in arterial and venous thrombo-occlusive diseases

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1155512

DOI=10.3389/fcvm.2023.1155512

ISSN=2297-055X

ABSTRACT=Evidence is mounting that NETosis, a programmed cell death in neutrophils, leading to the release of extracellular decondensed chromatin and pro-inflammatory as well as pro-thrombotic factors, is a pivotal element in atherosclerosis and venous thromboembolism. NETosis is based on a complex interplay between neutrophils and platelets or vice versa, a concept named immunothrombosis or thrombo-inflammation respectively, but the exact underlying molecular mechanisms and cellular interactions still need to be elucidated. Although primarily associated with the development of venous thromboembolic diseases, NETosis is also crucial in the development of atherosclerosis and its acute and chronic complications. Thus, this review presents a brief summary of the platelet and neutrophil physiology, cellular and molecular mechanisms underlying NETosis as well as NET-associated arterial and venous thrombo-inflammatory diseases and its potential prevention and treatment strategies.