AUTHOR=Chiu Ming-Huang , Chang Chia-Hsiu , Tantoh Disline Manli , Hsu Tsui-Wen , Hsiao Chih-Hsuan , Zhong Ji-Han , Liaw Yung-Po 

TITLE=Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1159764

DOI=10.3389/fcvm.2023.1159764

ISSN=2297-055X

ABSTRACT=Background: The aetio-pathologenesis of hypertension is multifactorial, encompassing genetic, epigenetic, and environmental factors. The combined effect of genetic and epigenetic changes on hypertension is not known. We evaluated the independent and interactive association of MTHFR rs1801133 single nucleotide polymorphism (SNP) and MTHFR promoter methylation with hypertension among Taiwanese adults.
Methods: We retrieved data including MTHFR promoter methylation, MTHFR rs1801133 genotypes (CC, CT, and TT), basic demography, personal lifestyle habits, and disease history of 1238 individuals from the Taiwan Biobank (TWB). 
Results: The distributions of hypertension and MTHFR promoter methylation quartiles (β<0.1338, 0.1338≤0.1385, 0.1385≤0.1423, and β≥0.1423 corresponding to