AUTHOR=Deng Hai-Wei , Mei Wei-Yi , Xu Qing , Zhai Yuan-Sheng , Lin Xiao-Xiong , Li Jie , Li Teng-Fei , Zheng Qian , Chen Jin-Sheng , Ou-Yang Shun , Huang Zhi-Bin , Cheng Yun-Jiu 

TITLE=The role of glucocorticoids in increasing cardiovascular risk

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1187100

DOI=10.3389/fcvm.2023.1187100

ISSN=2297-055X

ABSTRACT=Introduction: Different studies provide conflicting evidence regarding the potential for glucocorticoids (GCs) to increase the risk of cardiovascular diseases. This study performed a systematic review and meta-analysis to determine the correlation between GCs and cardiovascular risk, including major adverse cardiovascular events (MACE), death from any cause, coronary heart disease (CHD), heart failure (HF), and stroke. Methods: We performed a comprehensive search in PubMed and Embase (from inception to June 1, 2022). Studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the associations of interest were included. Results: A total of 43 studies with 15572512 subjects were included. Patients taking GCs had a higher risk of MACE (