AUTHOR=Qi Xiaoyi , Wang Shijia , Qiu Liangxian , Chen Xiongbiao , Huang Qianwen , Ouyang Kunfu , Chen Yanjun 

TITLE=Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1192664

DOI=10.3389/fcvm.2023.1192664

ISSN=2297-055X

ABSTRACT=Background: Although observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.We conducted a two-sample Mendelian randomization (MR) study to analyze the causal relationship between TIA and CAD using data from the FinnGen genome-wide association study. Analysis was performed using the inverse-variance weighted (IVW) method. The robustness of the results was evaluated using MR-Egger regression, the weighted median, MR pleiotropy residual sum, and outlier (MR-PRESSO) and multivariable MR analysis.Results: Results from IVW random-effect model showed that TIA was associated with an increased risk of coronary artery atherosclerosis (OR 1.17, 95%CI 1.06-1.28, P=0.002), ischemic heart disease (OR 1.15, 95%CI 1.04-1.27, P=0.007), and myocardial infarction (OR1.15, 95% CI 1.02-1.29, P=0.025). In addition, heterogeneity and horizontal pleiotropy were observed in the ischemic heart disease results, while the sensitivity analysis revealed no evidence of horizontal pleiotropy in other outcomes.This MR study demonstrated a potential causal relationship between TIA and CAD. Further research should be conducted to investigate the mechanism underlying the association.