AUTHOR=Korosoglou Grigorios , Giesen Alexander , Geiss Eva , Stach Ksenija 

TITLE=Case report: Strong low-density-cholesterol reduction accompanied by shrinkage of low-attenuation coronary plaque during lipid-lowering treatment with bempedoic acid—serial evaluation by coronary computed tomography angiography

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1203832

DOI=10.3389/fcvm.2023.1203832

ISSN=2297-055X

ABSTRACT=Herein we present a patient with coronary artery disease and prior percutaneous coronary interventions. In this patient, multiple statins and ezetimibe had to be discontinued due to intolerance with musculoskeletal complaints and nausea. Monotherapy with bembedoic acid was well tolerated and achieved exceptionally effective lipid-lowering, so that the LDL target of <55mg/dl could be successfully reached, as recommended by current guidelines. In addition, serial coronary computed tomography angiography (CCTA) performed upon clinical indications, during 20 months of lipid-lowering treatment with bembedoic acid, demonstrated signs of favorable plaque component modification, with shrinkage of low-attenuation plaque component compared to baseline findings.