AUTHOR=Coy-Canguçu Andréa , Antunes-Correa Lígia M. , Mazzali Marilda , Abrão Paula , Ronco Fernanda , Teixeira Cinthia Montenegro , Viana Karynna Pimentel , Cordeiro Guilherme , Longato Mauricio , Coelho Otávio Rizzi , Matos-Souza José Roberto , Nadruz Wilson , Sposito Andrei C. , Petersen Steffen E. , Jerosch-Herold Michael , Coelho-Filho Otávio Rizzi 

TITLE=Prognostic role of renal replacement therapy among hospitalized patients with heart failure in the Brazilian national public health system

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1226481

DOI=10.3389/fcvm.2023.1226481

ISSN=2297-055X

ABSTRACT=Data on patients hospitalized with acute heart failure in Brazil are scarce. We performed a cross-sectional, retrospective, records-based study using data retrieved from a large public database of heart failure admissions to any hospital from the Brazilian National Public Health System (SUS) (SUS Hospital Information System [SIHSUS] registry) to determine the in-hospital all-cause mortality rate, in-hospital renal replacement therapy rate and its association with outcome. In total, 910,128 hospitalizations due to heart failure were identified in the SIHSUS registry between April 2017 and August 2021, of which 106,383 (11.7%) resulted in in-hospital death. Renal replacement therapy (required by 8,179 non-survivors [7.7%] and 11,496 survivors [1.4%, p < 0.001]) was associated with a 56% increase in the risk of death in the univariate regression model (HR 1.56, 95% CI 1.52-1.59), a more than threefold increase of the duration of hospitalization, and a 45% or greater increase of cost per day. All forms of renal replacement therapy remained independently associated with in-hospital mortality in multivariable analysis (intermittent