AUTHOR=Ye Dan , Li Shuwen , Ding Yi , Ma Zhenqin , He Rongxia 

TITLE=Clinical value of mean platelet volume in predicting and diagnosing pre-eclampsia: a systematic review and meta-analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1251304

DOI=10.3389/fcvm.2023.1251304

ISSN=2297-055X

ABSTRACT=Background: Pre-eclampsia (PE) is a severe pregnancy complication. Thrombocytopenia and platelet dysfunction are common hematology disorder in PE. Among them, Mean Platelet Volume (MPV), a functional marker of platelets, has been considered by previous studies as a potentially useful predictor and diagnosis of PE. Methods: PubMed, CBM, CNKI, Embase, Wanfang, VIP and the Cochrane Library databases were retrieved to gather diagnostic trials for evaluating the diagnosis of PE in MPV, from their inception to March 13, 2023. We also Searched Google Scholar and Baidu Search. Results: 22 studies from 20 articles were found. The pooled diagnostic accuracy of the MPV for PE recognition was as follows: sensitivity 0.676 [95% CI (0.658-0.694)], specificity 0.710 [95% CI (0.703-0.717)], DOR 7.012 [95% CI (4.226-11.636)], SROC-AUC and Q* indices were 0.7889 and 0.7262. The pooled sensitivity, specificity, and DOR of MPV diagnostic PE before 16 weeks gestation was 0.707 [95% CI (0.670-0.743)], 0.639 [95% CI (0.611-0.667)] and 4.026 [95% CI (2.727-5.943)], the SROC-AUC and Q* indices were 0.7278 and 0.6753. For the interval of truncation values between 9 and 10 fL, the SROC-AUC and Q* indices for MPV were 0.8856 and 0.8162.Conclusions: Available evidence suggests that MPV has moderate predictive and diagnostic value for PE, particularly for diagnosis after 20 weeks of gestation. The diagnostic accuracy is higher when the MPV cut-off falls between 9 and 10 fL. The sensitivity of MPV alone in diagnosing PE is not high, and the combination of other markers for predictive diagnosis may better differentiate PE. Methods This meta-analysis was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines(29), and registration was completed with PROSPERO (CRD42023425154). We included diagnostic trials to investigate the predictive and diagnostic value of MPV for PE in pregnant women across all trimesters.