AUTHOR=Cioffi Giacomo Maria , Pinilla-Echeverri Natalia , Sheth Tej , Sibbald Matthew Gary TITLE=Does artificial intelligence enhance physician interpretation of optical coherence tomography: insights from eye tracking JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 10 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1283338 DOI=10.3389/fcvm.2023.1283338 ISSN=2297-055X ABSTRACT=The adoption of Optical Coherence Tomography (OCT) in percutaneous coronary intervention (PCI) is limited by need for real-time image interpretation expertise. Artificial intelligence (AI)-assisted Ultreon™ 2.0 software could address this barrier.We used eye-tracking to understand how these software changes impact viewing efficiency and accuracy.Methods: Eighteen interventional cardiologists and fellows at McMaster University, Canada were included and categorized as experienced or inexperienced based on lifetime OCT use. They were tasked with reviewing OCT images from both Ultreon™ 2.0 and AptiVue™ software platforms while their eye movements were recorded. Key metrics, such as time to first fixation on the area of interest, total task time, dwell time (time spent on the area of interest as a proportion of total task time), and interpretation accuracy, were evaluated using a mixed multivariate model.Physicians exhibited improved viewing efficiency with Ultreon™ 2.0, characterized by reduced time to first fixation (Ultreon™ 0.9 sec vs AptiVue™ 1.6 sec, p=0.007), reduced total task time (Ultreon™ 10.2 sec vs AptiVue™ 12.6 sec, p=0.006), and increased dwell time in the area of interest (Ultreon™ 58% vs AptiVue™ 41%, p<0.001). These effects were similar for experienced and inexperienced physicians. Accuracy of OCT image interpretation was preserved in both groups, with experienced physicians outperforming inexperienced physicians.Discussion: Our study demonstrated that AI-enabled Ultreon™ 2.0 software can streamline the image interpretation process and improve viewing efficiency for both inexperienced and