AUTHOR=Tan Chao-Di , Liu Juan-Zhang , Zheng Yu-Ping , Li Zong-jian , Zhou Shu-Xian 

TITLE=Left atrial enlargement and high uric acid level are risk factors for left atrial thrombus or dense spontaneous echo contrast in atrial fibrillation patients with low to moderate embolic risk assessed by CHA2DS2-VASC score

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.937770

DOI=10.3389/fcvm.2023.937770

ISSN=2297-055X

ABSTRACT=A total of 849 inpatients diagnosed with atrial fibrillation who had low to moderate CHA2DS2- VASc scores and complete transesophageal echocardiography were included in this study. Among them, 66 patients had left atrial thrombus or dense spontaneous echo contrast. When different models were used to correct other known risk factors, abnormal serum uric acid levels and abnormal left atrial diameter were identified as additional risk factors for left atrial thrombus or dense spontaneous echo contrast. The incidence of left atrial thrombus or dense spontaneous echo contrast was higher in patients with abnormal serum uric acid levels than in the control group (12.4% vs. 5.6%, p<0.05), and this difference persisted after correcting the baseline data with propensity score matching (10.6% vs. 4.1%, p<0.05). Abnormal left atrial diameter was another risk factor suggested by regression analysis, with an increased incidence of left atrial thrombus or dense spontaneous echo contrast in the abnormal left atrial diameter group compared to the control group, both before (18.0% vs. 3.5%, p<0.05) and after (15.5% vs. 5.2%, p<0.05) propensity score matching. The best predictive value was obtained by adding both abnormal serum uric acid levels and abnormal left atrial diameter.