AUTHOR=Zhou Ke , Xiang Jie , Li Guo-yong , Pu Xiao-bo , Zhang Li 

TITLE=Body composition and mortality in a cohort study of Chinese patients with hypertrophic cardiomyopathy

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.988274

DOI=10.3389/fcvm.2023.988274

ISSN=2297-055X

ABSTRACT=Objective:To analyse the characteristics and mortality of hypertrophic cardiomyopathy (HCM) patients with different body compositions.
Methods:This study included 530 consecutive patients with HCM from November 2008 to May 2016 at West China Hospital. Percent body fat (BF) and lean mass index (LMI) were calculated using an equation based on body mass index (BMI). Patients were divided into five sex-specific BMI, BF and LMI quintiles.
Results:The average BMI, BF and LMI were 23.1±3.2 kg/m2, 28.1±7.3% and 16.5±2.2 kg/m2, respectively. Patients with higher BMI or BF were older and had more symptoms and adverse cardiovascular conditions; those with higher LMI were younger and had less coronary artery disease and lower serum NT-proBNP and creatine. BF correlated positively with resting left ventricular (LV) outflow tract gradient, mitral regurgitation (MR) degree and left atrial diameter but was inversely associated with septal wall thickness (SWT), posterior wall thickness (PWT), LV mass, and E/A ratio; LMI was positively correlated with SWT, LV end diastolic volume and LV mass but was negatively associated with MR degree. During a median follow-up of 33.8 months, 48 all-cause deaths occurred. Reversed J-shape associations of BMI and LMI with mortality were observed. A lower BMI or LMI was significantly associated with high mortality, especially for low-moderate BMI and LMI. No significant difference in mortality was found across BF quintiles.
Conclusions:The associations of BMI, BF and LMI with baseline characteristics and cardiac remodelling are different in HCM patients. Low BMI and LMI, but not BF, predicted mortality in Chinese HCM patients.