AUTHOR=Hu Xiang-zhi , Fu Ling-ling , Ye Bin , Ao Man , Yan Ming , Feng Hong-chao TITLE=Gut microbiota and risk of coronary heart disease: a two-sample Mendelian randomization study JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 11 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1273666 DOI=10.3389/fcvm.2024.1273666 ISSN=2297-055X ABSTRACT=The relationship between gut microbiota composition and coronary heart disease (CHD) has been recently reported in several observational studies. However, the causal effect of gut microbiota on Coronary heart disease is uncharted.OBJECTIVE: This study attempted to investigate the effect of gut microbiota on coronary heart disease by Mendelian randomized analysis. METHODS: Through the two-sample MR method, single nucleotide polymorphisms (SNPs) relevant to gut microbiota were selected as instrument variables (IVs) to evaluate the causal association between gut microbiota and the risk of CHD.RESULTS: According to the selection criteria of inverse-variance-weighted (IVW) that Class.