AUTHOR=Lu Keji , Ye Xianglin , Chen Yaoxuan , Wang Peng , Gong Meiting , Xuan Bing , Tang Zhaobing , Li Meiling , Hou Jun , Peng Ke , Pei Haifeng 

TITLE=Research progress of drug eluting balloon in arterial circulatory system

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1287852

DOI=10.3389/fcvm.2024.1287852

ISSN=2297-055X

ABSTRACT=The arterial circulatory system diseases are common in clinical practice, and their treatment options have been of great interest due to their high morbidity and mortality. Drug-eluting balloons, as a new type of endovascular interventional treatment option, can avoid the long-term implantation of metal stents and is a new type of angioplasty without stents, so drug-eluting balloons have better therapeutic effects in some arterial circulatory diseases and have been initially used in clinical practice. In this review, we first describe the development, process, and mechanism of drug-eluting balloons. Then we summarize the current studies on the application of drug-eluting balloons in coronary artery lesions, instent restenosis, and peripheral vascular disease. As well as the technical difficulties and complications in the application of drug-eluting balloons and possible management options, in order to provide ideas and help for future in-depth studies and provide new strategies for the treatment of more arterial system diseases.1. We describe the development, process, and mechanism of drug-eluting balloons.2. We summarize the current studies on the application of drug-eluting balloons in coronary artery lesions, in-stent restenosis and peripheral vascular disease.3. We have summarized numerous clinical trials and demonstrated the safety and effectiveness of drug-eluting balloons in the treatment of diseases including coronary heart disease and lower extremity vascular disease ： ① For small vessel, large vessel and bifurcation lesions of coronary artery, their short term efficacy is favorable and safety is high, while their long term efficacy for large vessel lesions of coronary artery is also excellent ② For femoral and popliteal arteries, their performance is also sound ③ For renal blood vessels, children's cardiac vessels and in-stent restenosis, there have been studies or reports proving their treatment feasibility, but a large number of studies are needed to prove their safety and efficacy. 4. By reviewing the progress of drug-eluting balloon research mentioned above, we can provide new ideas for the treatment of more arterial system diseases.