AUTHOR=Shankhwar Vishwajeet , Urvec Janez , Steuber Bianca , Schmid Zalaudek Karin , Saloň Adam , Hawliczek Anna , Bergauer Andrej , Aljasmi Khawla , Abdi Asrar , Naser Asmaa , Himeidi Maya , Alsuwaidi Hanan , Du Plessis Stefan , Alsheikh-Ali Alawi , Kellett Catherine , Bayoumi Riad , Blaber Andrew Phillip , Goswami Nandu 

TITLE=Effects of menstrual cycle on hemodynamic and autonomic responses to central hypovolemia

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1290703

DOI=10.3389/fcvm.2024.1290703

ISSN=2297-055X

ABSTRACT=Background: Estrogen and progesterone levels undergo changes throughout the menstrual cycle.Existing literature regarding the effect of menstrual phases on cardiovascular and autonomic regulation during central hypolemia is contradictory.This study aims to explore the influence of menstrual phases on cardiovascular and autonomic responses in both resting and during the central hypovolemia induced by lower body negative pressure (LBNP). This is a companion paper, in which data across the menstrual phases from healthy young females, whose results are reported in Shankwar et al ( 2023), were further analysed.The study protocol consisted of three phases: 1) 30 minutes of supine rest; 2) 16 minutes of four LBNP levels; and 3) 5 minutes of supine recovery. Hemodynamic and autonomic responses (assessed via heart rate variability, HRV) were measured before-, during-, and after-LBNP application using Task Force Monitor® (CNSystems, Graz, Austria). Blood was also collected to measure estrogen and progesterone levels.In this companion paper, we have exclusively assessed 14 females from the previous study