AUTHOR=Peng Hui , Wang Xugang , Zhang Longfei , Su Yang , Yan Jieli , Wu Xin 

TITLE=Correlation of the serum cell division cycle 42 with CD4+ T cell subsets and in-hospital mortality in Stanford type B aortic dissection patients

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1324345

DOI=10.3389/fcvm.2024.1324345

ISSN=2297-055X

ABSTRACT=Objective: Cell division cycle 42 (CDC42) regulates CD4+ T-cell differentiation and participates in vascular stiffness and atherosclerosis and is involved in the progression of Stanford type B aortic dissection (TBAD). This study aimed to explore the correlation between serum CDC42 level and CD4+ T cell subsets and in-hospital mortality in TBAD patients.
Methods: Serum CDC42 and peripheral blood T-helper (Th) 1, Th2, and Th17 cells were detected in 127 TBAD patients by enzyme-linked immunosorbent assay and flow cytometry, respectively. Serum CDC42 was also quantified in 30 healthy controls.
Results: Serum CDC42 was decreased in TBAD patients versus healthy controls (median (interquartile range (IQR)): 418.0 (228.0-761.0) pg/mL versus 992.0 (716.3-1445.8) pg/mL, P<0.001). In TBAD patients, serum CDC42 was negatively correlated with Th17 cells (P=0.001), but not Th1 (P=0.130) or Th2 cells (P=0.098). Seven (5.5%) patients experienced in-hospital mortality. Serum CDC42 was reduced in patients who experienced in-hospital mortality versus those who did not (median (IQR): 191.0 (145.0-345.0) pg/mL versus 451.5 (298.3-766.8) pg/mL, P=0.006). By receiver operating characteristic analysis, serum CDC42 showed a good ability for estimating in-hospital mortality (area under curve=0.809, 95% confidence interval (CI)=0.662-0.956). By the multivariate logistic regression analysis, elevated serum CDC42 (odd ratio (OR)=0.994, 95% CI=0.998-1.000, P=0.043) was independently correlated with lower risk of in-hospital mortality, while higher age (OR=1.157, 95% CI=1.017-1.316, P=0.027) was an independent factor for increased risk of in-hospital mortality.
Conclusion: Serum CDC42 negatively associates with Th17 cells and is independently correlated with decreased in-hospital mortality risk in TBAD patients.