AUTHOR=Oh Ah Ran , Kwon Ji-Hye , Park Jungchan , Min Jeong-Jin , Lee Jong-Hwan , Yoo Seung Yeon , Lee Dong Jae , Kim Wooksung , Cho Hyun Sung , Kim Chung Su , Lee Sangmin Maria 

TITLE=Preoperative C-reactive protein/albumin ratio and mortality of off-pump coronary artery bypass graft

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1354816

DOI=10.3389/fcvm.2024.1354816

ISSN=2297-055X

ABSTRACT=Background: We sought to investigate the prognostic value of preoperative C-reactive protein (CRP)-to-albumin ratio (CAR) for the prediction of mortality in patients undergoing off-pump coronary artery bypass grafting (OPCAB).Methods: From January 2010 to August 2016, adult patients undergoing OPCAB were analyzed retrospectively. In a total of 2,082 patients, preoperative inflammatory markers including CAR, CRP, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were recorded. Receiver operating characteristic (ROC) curves were used to determine the optimal threshold and compare the predictive values of the markers. The patients were divided into two groups according to the cut-off value of CAR, and then the outcomes were compared.The primary end point was one-year mortality.Results: During the one-year follow-up period, 25 patients (1.2%) died after OPCAB. The area under the curve of CAR for one-year mortality was 0.767, which was significantly higher than other inflammatory markers. According to the calculated cut-off value of 1.326, the patients were divided into two groups: 1,580 (75.9%) patients were placed in the low CAR group vs. 502 (24.1%) patients in the high CAR group. After adjustment with inverse probability weighting, high CAR was significantly associated with increased risk of one-year mortality after OPCAB (Hazard ratio, 5.01; 95% Confidence interval, 2.01 -12.50; p < 0.001).In this study, we demonstrated that preoperative CAR was associated with oneyear mortality following OPCAB. Compared to previous inflammatory markers, CAR may offer superior predictive power for mortality in patients undergoing OPCAB. For validation of our findings, further prospective studies are needed.