AUTHOR=Santos Luciano de Moura , Luz Larissa Santos , Bastos Vinicius Lelis , Barcelos Tulio Assunção , Abreu Frederico André Alves , Beck Leonardo Cogo , Darnasser Mohammed Jamal Aldin Hilal , Cruz Francisco de Assis , Matos Luis Carlos Vieira , Carvalho Wenderval Borges 

TITLE=Case Report: Transcatheter aortic valve implantation using balloon-expandable bioprosthesis in patients with severe pure aortic regurgitation on noncalcified native valves: a series of cases

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1365181

DOI=10.3389/fcvm.2024.1365181

ISSN=2297-055X

ABSTRACT=Background: For individuals with pure aortic regurgitation (AR), transcatheter aortic valve implantation (TAVI) is cautiously recommended only for those with a high or prohibitive surgical risk. We aimed to describe the results of a case series of transcatheter implantation of a balloon-expandable aortic valve bioprosthesis (BEV) for the treatment of non-calcified native valve AR.Methods: From February 2022 to November 2022, we performed TAVI in patients with severe pure AR. Cases were indicated on the basis of symptoms, high/prohibitive surgical risk, or patient refusal of conventional treatment.Results: Five patients underwent successful TAVI. The mean age was 81.9±6.6 years, 3 (60%) female and 5 (100%) in NYHA class III or IV. The baseline echocardiogram showed an ejection fraction of 49.0±10.6 and left ventricular end-systolic diameter 28.5±4.7 mm/m². The average area of the aortic annulus was 529.1±47.0 and the area oversizing index was 17.6±1.2.In the 30-day follow-up, there were no cases of prosthesis embolization, annulus rupture, stroke, acute myocardial infarction, acute renal failure, hemorrhagic complication or death.One patient required a permanent pacemaker and another had a minor vascular complication.The clinical follow-up were 19.8 months (16.7 -21.8). During this period, all patients remained alive and in NYHA class I or II. One of the patients developed a moderate paravalvular leak.TAVI with a BEV proved to be safe and effective in this small case series of patients with non-calcified native valve AR in a follow-up longer than 1 year.