AUTHOR=Ma Juan , Wu Peng , Ma Shengzong , Ma Xueping , Jin Ping , Jia Shaobin 

TITLE=The triglyceride–glucose index is associated with no-reflow phenomenon in STEMI patients with type 2 diabetes after percutaneous coronary intervention

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1386318

DOI=10.3389/fcvm.2024.1386318

ISSN=2297-055X

ABSTRACT=The relationship between the triglyceride-glucose (TyG) index and no-reflow phenomenon after percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (T2DM) and acute ST-segment elevation myocardial infarction (STEMI) remains unclear. The aim of this study was to investigate the relationship between baseline TyG index and no-reflow phenomenon in STEMI patients with T2DM after PCI.This study enrolled 695 patients with T2DM and STEMI from the General Hospital of Ningxia Medical University (2014)(2015)(2016)(2017)(2018)(2019). Patients were divided into tertiles according to the TyG index levels. The incidence of no-reflow phenomenon was recorded. A multivariate regression model was developed to analyze the association between baseline TyG index and no-reflow phenomenon. The linear association between baseline TyG index and no-reflow phenomenon was explored using smooth curve fitting with parallel subgroup analyses. Receiver operating characteristic (ROC) curve were generated to determine predictive power of TyG index.A multivariate logistic regression model revealed that the TyG index was an independent risk factor of no-reflow phenomenon [OR=3.23,95%CI: 2.15-4.86, P<0.001], and the occurrence of no-reflow phenomenon increased gradually with the increase of TyG index tertile interval (P < 0.001). Smooth curve fitting showed that TyG index was linearly related to the risk of no-reflow. Subgroup analysis showed that they participated in this positive correlation. The area under ROC curve (AUC) of the TyG index for evaluating the occurrence of No-reflow was 0.710 (95% CI 0.640-0.780; p＜0.01).Conclusions TyG index is independently associated with no-reflow phenomenon, suggesting that the simple index of TyG index can be used for risk assessment of no-reflow phenomenon after PCI in STEMI patients with T2DM.