AUTHOR=Schmid M. E. , Dolata L. , König H. , Stock S. , Klotz S. G. R. , Girdauskas E. TITLE=An implementation manual for an interprofessional enhanced recovery after surgery protocol in cardiac surgery following international established frameworks JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 11 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1392881 DOI=10.3389/fcvm.2024.1392881 ISSN=2297-055X ABSTRACT=Enhanced Recovery After Surgery (ERAS) protocols represent a paradigm shift in perioperative care, aim to optimize patient outcomes and accelerate recovery. This guidelinemanual presents findings from implementing the INCREASE study, a bi-centric prospective randomized controlled trial focusing on ERAS in minimally invasive heart valve surgery. Utilizing the Consolidated Framework for Implementation Research (CFIR) and the Template for Intervention Description and Replication (TIDieR), the study examined contextual factors, intervention components, and implementation strategies.Key findings from the CFIR analysis revealed critical domains influencing implementation success. These included innovation characteristics, external and internal settings, and individual dynamics. The study showcased ERAS's adaptability to diverse healthcare systems, emphasizing its potential for successful integration across varying contexts. Furthermore, the importance of interprofessional collaboration emerged as a foundation of practical implementation, fostering teamwork, communication, and patient-centered care. Utilizing the TIDieR framework, this guidelinemanual comprehensively describes ERAS intervention components, detailing pre-operative counseling, intraoperative management, and postoperative care strategies. The guidelines manual underscored the importance of tailored, patientcentered approaches, highlighting the role of an academic ERAS nurse, early mobilization, and psychosomatic interventions in promoting optimal recovery outcomes.In conclusion, the INCREASE study provided valuable insights for creating an implementation guidelinemanual for ERAS in cardiac surgery, emphasizing adaptability, collaboration, and ongoing evaluation as key drivers of successful implementation. These findings have broad implications for improving patient care outcomes and advancing perioperative practices in cardiac surgery settings.