AUTHOR=Liu Yuting , Qiu Zifeng , Shen Geng , Sun YangYang , Mei Jiarong , Liu Zhihao , Wang Leyi , Li Jianping 

TITLE=Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in general population: evidence from NHANES 1999–2010

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1393513

DOI=10.3389/fcvm.2024.1393513

ISSN=2297-055X

ABSTRACT=In this cohort study, during 270014 person-years of follow-up, 4074 all-cause deaths and 1116 CVDcause deaths were documented. NPAR levels exhibited significant nonlinear associations with both CVD-cause (P=0.018 for nonlinearity) and all-cause mortality (P<0.001 for nonlinearity). Participants in the highest NPAR tertile had a significantly increased risk of all-cause mortality (HR: 1.46, 95% CI: 1.33-1.61) and CVD-cause mortality (HR: 1.54, 95% CI: 1.32-1.80) compared to those in the lowest tertile in the fully adjusted model, while no association was detected for individuals in the middle tertile. Further ROC analysis confirmed that NPAR had higher predictive value than neutrophil percent segment and SII.Elevated NPAR level was significantly associated with an increased risk of all-cause and CVD-cause mortality in general population. The high predictive value of NPAR, combined with the easy-tocalculate property, suggests that its potential as a novel inflammatory indicator is worthy of further investigation.