AUTHOR=Fang Yunteng , Shen Jiayi , Lyu Lingchun 

TITLE=Value of the triglyceride–glucose index and related parameters in heart failure patients

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1397907

DOI=10.3389/fcvm.2024.1397907

ISSN=2297-055X

ABSTRACT=The triglyceride--glucose (TyG) index, proven to be an essential insulin resistance (IR) biomarker (better than Homeostasis Model Assessment for Insulin Resistance (HOMA-IR)), is simple and noninvasive. Recently, indisputable evidence has shown that the TyG index is strongly associated with cardiovascular disease (CVD; including atherosclerosis, heart failure (HF) and hypertension) prognosis and mortality. Nevertheless, the value of the TyG index in HF patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2is) has not been systematically evaluated.Therefore, in this review, we summarized the value of the TyG index and its related parameters as markers of CVD, especially HF. Furthermore, we addressed SGLT2is and GLP-1 receptor antagonists(GLP-1 RAs) use in HF patients. Finally, we summarized the mechanism of the "obesity paradox".