AUTHOR=Lin Yi-Hung , Lin Meng-Hung , Shi Chung-Sheng , Lin Yu-Sheng , Lin Chun-Liang , Yang Yao-Hsu , Liao Yu-San , Chen Mei-Yen , Tsai Ming-Horng , Lin Ming-Shyan 

TITLE=The impact of fetuin-A on predicting aortic arch calcification: secondary analysis of a community-based survey

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1415438

DOI=10.3389/fcvm.2024.1415438

ISSN=2297-055X

ABSTRACT=Introduction: Atherosclerotic cardiovascular disease is associated with a high mortality rate due to vascular calcification. The role of fetuin-A in aortic arch calcification (AAC) is less well understood.Methods: An analysis of secondary biomarkers was performed on 800 individuals from the biobank using the community database. AAC was defined by radiologists based on imaging.Multiple variables logical analysis was used for risk analysis.Results: A total of 736 individual samples were collected based on age and gender finally.There is an average age of 65 ± 10 years old, and half the population is male. In spite of similar body weight, renal function, and hepatic function, the AAC group had higher blood pressure and fetuin-A levels independently: systolic blood pressure (SBP) index ≥ 130 mmHg (adjusted odd ratio (aOR) 1.85, 95% confidence interval (CI) 1.34-2.57, p = 0.002) and fetuin-A (aOR 0.62, 95% CI 0.50-0.76, p < 0.001). Moreover, it is evident that AAC can be predicted more accurately when combined with SBP ≥ 130 mmHg and a low fetuin-A level (< 358 μg/mL): aOR 5.39, 95% CI 3.21-9.08) compared to the reference.Low fetuin-A levels are significantly correlated with AAC while there is an increased association between vascular calcification and coexisting hypertension.