AUTHOR=Kirchner Johannes , Gerçek Muhammed , Omran Hazem , Friedrichs Kai Peter , Rudolph Felix , Rossnagel Tobias , Piran Misagh , Goncharov Arseniy , Ivannikova Maria , Rudolph Volker , Rudolph Tanja Katharina 

TITLE=Predictive value of CT-based and AI-reconstructed 3D-TAPSE in patients undergoing transcatheter tricuspid valve repair

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1463978

DOI=10.3389/fcvm.2024.1463978

ISSN=2297-055X

ABSTRACT=BackgroundThe tricuspid annular plane systolic excursion (TAPSE) assessed by echocardiography has failed in predicting outcomes in patients with severe tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve intervention (TTVI). Considering the complex shape of the tricuspid annulus and right ventricle, as well as the difficult echocardiographic image acquisition of the right heart, cardiac computed tomography (CT) might be superior for the analysis of the annular excursion. Thus, this study aimed to analyze whether CT-captured TAPSE provides additional value in predicting outcomes after TTVI.Methods and resultsFor TTVI procedure planning, 75 patients (mean age, 77 ± 8 years; 61% female) with severe TR underwent full cardiac cycle CT. Septal, lateral, anterior, and posterior TAPSE, as well as TAPSE- volume, were analyzed. Indexed anterior and posterior (iTAPSE) and TAPSE volume were reduced in patients with right ventricular ejection fraction <45%. At 1 year after TTVI (mean follow-up, 193 ± 146days), the combined endpoint of death and rehospitalization occurred in significantly fewer patients with posterior iTAPSE >4.5 mm/m2 (17.2% vs. 63.6%; HR 0.225, CI 0.087–0.581; P < 0.001) and in patients with iTAPSE volume >9 ml/m2 (16.4% vs. 57.1%; HR: 0.269 CI 0.105–0.686; P = 0.003). Echocardiographic TAPSE correlated best with lateral CT-based TAPSE, although both failed in predicting outcomes after TTVI. In multivariate Cox regression, posterior iTAPSE was found to be a significant predictor of outcome 1 year after TTVI.ConclusionsPosterior iTAPSE is an independent predictor of cardiovascular outcomes among patients undergoing TTVI. Furthermore, CT-measured TAPSE has incremental value and refines risk stratification for clinical outcomes in patients undergoing TTVI.