AUTHOR=Qi Chuyao , Wang Wenting , Liu Yanfei , Hua Tianfeng , Yang Min , Liu Yue 

TITLE=Heart-brain interactions: clinical evidence and mechanisms based on critical care medicine

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1483482

DOI=10.3389/fcvm.2024.1483482

ISSN=2297-055X

ABSTRACT=In this review paper, we search the recent literature regarding the application of the heart-brain interaction theories in the field of intensive care unit. Simultaneously, we methodically summarize the clinical evidence supporting its application in intensive care unit treatment, based on clinical randomized trials and clinical case studies. We delve into how it's applied in treating severely ill patients and in researching animal models for cardio-cerebral comorbidities, aiming to supply benchmarks for subsequent clinical trials and studies on mechanisms.