AUTHOR=Wu Zhenni , Xie Mingxing , Zhang Li , He Qing , Gao Lang , Ji Mengmeng , Lin Yixia , Li Yuman 

TITLE=Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 11 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1504063

DOI=10.3389/fcvm.2024.1504063

ISSN=2297-055X

ABSTRACT=Valvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RV–PA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the right ventricle cannot adapt to the elevated afterload by increasing its contractile function, RV-PA uncoupling occurs. RV-PA uncoupling has been shown to be associated with poor outcomes in VHD. This review summarizes the prognostic significance of RV-PA coupling in patients with VHD.