AUTHOR=Feng Dandan , Wang Jianchun 

TITLE=Factor XI inhibitors are the novel promising anticoagulants in the treatment of age related thrombotic disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1498826

DOI=10.3389/fcvm.2025.1498826

ISSN=2297-055X

ABSTRACT=The incidence and mortality of thrombotic diseases in the aged population are increasing year by year, which seriously affect the quality of life of the elderly. At present, antithrombotic drugs used in clinical practice have good efficacy, but they caused different degrees of age-dependent bleeding risk. Therefore, there is an urgent need to develop effective antithrombotic drugs with less risk of bleeding. Recent studies have shown that factor Ⅺ inhibitors can effectively reduce the incidence of thromboembolic events without increasing the risk of bleeding. Therefore, factor Ⅺ inhibitors are expected to be safe and effective new anticoagulants, providing a new sight for the prevention and treatment of thrombotic diseases. This paper reviews the biological functions of factor Ⅺ, the types and characteristics of factor Ⅺ inhibitors and the related research progress of factor Ⅺ inhibitors.