AUTHOR=Wen Huan , Su Bo , Liu Jinbo , Wang Hongyu 

TITLE=Novel insights into the association between organ damage and inflammatory response in preoperative abdominal aortic aneurysms

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1511112

DOI=10.3389/fcvm.2025.1511112

ISSN=2297-055X

ABSTRACT=BackgroundAbdominal aortic aneurysm (AAA) is a life-threatening condition in the elderly population. The insidious nature of AAA onset makes early detection difficult. Currently, there are few studies on changes in laboratory parameters during AAA development.MethodsThis study included 55 elderly patients with AAA who were admitted to the Department of Vascular Medicine, Shougang Hospital, Peking University 2021–2022. Propensity score matching (PSM) in a 1:1 ratio was performed to match the 55 patients and 1,031 controls. In this population of AAA, correlation and regression analyses were used to explore the association between the level of inflammation and each laboratory parameter.ResultsCompared to the control group, significant differences in inflammatory markers, transaminase and bilirubin levels, blood urea nitrogen (BUN) and creatinine (Cr) levels, and ankle-brachial index were found in the aneurysm group. After PSM, the differences between the two groups for each parameter remained statistically significant. Correlation and regression analyses showed a weak positive correlation between the inflammatory index and the BUN and Cr levels (correlation coefficient = 0.22).ConclusionsOur study demonstrates the presence of a highly inflammatory state and damage to various organs in patients with AAA. This hyperinflammatory state may be associated with kidney injury and is a cause of concern.