SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Bibliometric Analysis of Studies on the lipid management of coronary heart disease from 2014 to 2023
Provisionally accepted
- 1Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
- 2Beijing University of Chinese Medicine, Beijing, China
- 3Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
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Objective: The incidence of coronary heart disease (CHD) is progressively increasing on an annual basis. Dyslipidemia constitutes a significant pathogenic factor in CHD, exerting a substantial influence on its onset and progression. Consequently, precise and effective lipid management is crucial for the prevention and cure of CHD. This study aims to examine the risk factors, therapeutic approaches, current research status and emerging trends in lipid management related to CHD. Method: We searched for publications on lipid management of coronary heart disease from 01/01/2014 to 12/31/2023 in Web of Science and performed bibliometrics using CiteSpace, VOSviewer, Scimago Graphica, Gephi and R Studio. Results: A total of 6,027 related articles were retrieved from the Web of Science database. After screening, 5,954 articles were included. Journal of Clinical Lipidology and Atherosclerosis were the journals with the most publications and citations, respectively. In this discipline, the United States has the largest number of publications, research institutions, citations, and collaborative partnerships. The burst keywords include sex difference, heterozygote familial hypercholesterolemia, PCSK9, lipid peroxidation, fish oil, monoclonal antibody, insulin sensitivity, and gene, etc. Conclusion: Research on CHD indicates that risk factors influencing lipid levels encompass sex, genetics, PCSK9, and lipid peroxidation. There has been a growing trend in investigating the underlying mechanisms of these factors. Recent research hotspots have concentrated on disease prevention, prognosis, specific treatments for CHD, the development of new pharmaceuticals, and the molecular mechanisms of action. Future research is likely to continue focusing on more precise treatment protocols and the exploration of novel mechanisms.
Keywords: coronary heart disease, lipid management, Bibliometrics, Web of Science, Risk factors
Received: 18 Oct 2024; Accepted: 08 Dec 2025.
Copyright: © 2025 Liu, Ji, Zhao, LIANG, Yang, Shi and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shuai Shi
Yuanhui Hu
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