AUTHOR=Saraiva Laura Smaniotto , Frigieri Gustavo , Eibel Bruna , Barbosa Eduardo Costa Duarte 

TITLE=Brain compliance: a new assessment for clinical practice?

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1526017

DOI=10.3389/fcvm.2025.1526017

ISSN=2297-055X

ABSTRACT=The correlation between pulse wave velocity (PWV) and brain compliance acquired using Brain4care (B4C) monitors is an emerging field of study that aims to better understand cerebrovascular health and its implications for cognitive function and brain aging. Increased arterial stiffness, often due to aging or hypertension, impairs brain compliance, which is crucial for maintaining cerebral homeostasis. This impairs cerebral perfusion, causing microvascular brain damage, which may contribute to long-term cognitive impairment. The B4C sensors monitor cerebral compliance through the analysis of pulsatile waves derived from the cardiac cycle and has already demonstrated a significant correlation with invasive intracranial pressure (ICP) parameters, with the advantage of being non-invasive, reusable, portable, and can be used in several clinical conditions, such as intracranial hypertension (ICH) and hydrocephalus. These methods have the potential to improve the monitoring of cerebral compliance and ICP, with the benefit of avoiding the risks associated with invasive methods. The correlation between PWV and brain compliance acquired using B4C monitors highlights the importance of monitoring vascular health to preserve brain function. Increased arterial stiffness, reflected by increased PWV, is associated with decreased brain compliance, which may have significant implications for cognitive health and the risk of cerebrovascular disease.