AUTHOR=Wang Ying , Wang Jun , Lv Wang , Chen Hu , Zhang Yang , Yang Qian , Ma Xiaoli , Guo Run , Zhang Qianyu 

TITLE=Influence of Zhigancao decoction on chronic heart failure combined with depression

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1538940

DOI=10.3389/fcvm.2025.1538940

ISSN=2297-055X

ABSTRACT=Chronic heart failure (CHF) combined with depression represents a significant clinical challenge due to the mutual exacerbation of physical and psychological symptoms. This study investigated the therapeutic effects of Zhigancao decoction, a traditional Chinese medicine, in combination with conventional Western treatments in patients with CHF and depression. A total of 122 patients were enrolled and divided into two groups: a control group receiving standard Western treatment, and an observation group receiving Zhigancao decoction in addition to conventional therapy. Outcomes were assessed by evaluating the clinical efficacy, cardiac function, inflammatory markers, depressive symptoms, and quality of life. The Zhigancao decoction group exhibited significantly higher efficacy rates, improved left ventricular ejection fraction (LVEF), reduced levels of inflammatory markers [N-terminal pro-brain natriuretic peptide (NT-proBNP), matrix metalloproteinase-9 (MMP-9), and high-sensitivity C-reactive protein (hs-CRP)], and lower scores on depression scales, compared to the control group. Furthermore, the quality of life significantly improved in the Zhigancao decoction group. These findings underscore the potential of Zhigancao decoction as an effective adjunct to conventional treatments for managing CHF combined with depression, offering a holistic approach that integrates physical and mental health improvements.