AUTHOR=Pena Diana-Ligia , Aurelian Justin , Grigore Mihai , Hodorogea Andreea-Simona , Weiss Emma , Bădilă Elisabeta , Ilieșiu Adriana-Mihaela , Balahura Ana-Maria 

TITLE=Emerging therapeutic frontiers in hypertension management

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1550181

DOI=10.3389/fcvm.2025.1550181

ISSN=2297-055X

ABSTRACT=Resistant hypertension, characterized by persistently elevated blood pressure despite adherence to multiple antihypertensive therapies, remains a significant global health challenge. This condition is associated with increased cardiovascular morbidity and mortality, highlighting the urgent need for more effective treatment strategies. While current management focuses on lifestyle modification and pharmacotherapy, many patients do not achieve target blood pressure levels. Recent advances have led to the development of emerging therapies targeting novel mechanisms, including gene silencing, receptor modulation, enzyme inhibition, and immunomodulation. This descriptive review examines the efficacy, safety, and clinical trial progress of these innovative therapeutic approaches, offering new hope for improved blood pressure control in resistant hypertension.