AUTHOR=Barazi Muhi Dean , Bade Yusuf , Zanbrakji Malek , Stone Patrick A. , Sabbagh Omar Belal , Ali Mohsin H. , Melamud Alexander 

TITLE=Case Report: Paracentral acute middle maculopathy following carotid artery dissection

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1560482

DOI=10.3389/fcvm.2025.1560482

ISSN=2297-055X

ABSTRACT=BackgroundParacentral acute middle maculopathy (PAMM) is a rare, presumed ischemic maculopathy. While primarily associated with retinal vascular pathologies, several case studies have documented PAMM diagnoses following systemic cardiovascular events or interventions. Here, we discuss a case of PAMM development after carotid artery dissection (CAD).Case presentationA woman in her late 30 s presented to the emergency department with transient right-side weakness and amaurosis in her left eye lasting 1–2 h. An initial stroke and embolic workup showed no significant findings. She later presented to the retina clinic with normal visual acuity and intraocular pressure. Dilated fundus examination, intravenous fluorescein angiography, and spectral-domain optical coherence tomography (SD-OCT) were unremarkable. Several days later, the patient returned to the emergency department complaining of transient ride-sided paresthesia, transient facial weakness, and dysarthria. A computed tomography angiogram revealed a dissection of the left internal carotid artery. Repeated retinal evaluation revealed a hyperreflective band on SD-OCT, characteristic of PAMM, spanning from the inner plexiform layer to the outer plexiform layer. Subsequent SD-OCT scans showed a resolution of the acute hyperreflective PAMM lesion with corresponding attenuation of the affected inner nuclear layer. Follow-up visits indicated a residual inferior paracentral scotoma in the affected eye.ConclusionsThis case illustrates the rare occurrence of PAMM associated with CAD, underscoring the link between systemic vascular events and retinal ischemia, and demonstrating the potential of PAMM as an early indicator of the causative vascular pathology.