AUTHOR=Liu Xu , Wang Jing , Tong Yan , Wang Shuai 

TITLE=The power of the left atrioventricular coupling index in cardiovascular disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1567856

DOI=10.3389/fcvm.2025.1567856

ISSN=2297-055X

ABSTRACT=The left atrioventricular coupling index (LACI) has emerged as a novel and transformative biomarker in cardiovascular research, addressing long-standing limitations in traditional cardiac function assessments. By quantifying the ratio of left atrial to left ventricular end-diastolic volumes, LACI offers unprecedented prognostic insights into a wide range of cardiovascular diseases, including atrial fibrillation, heart failure, and myocardial infarction, as well as other conditions such as hypertension and cardiomyopathies. Recent evidence highlights its unique ability to integrate atrial and ventricular dynamics, offering a more comprehensive perspective on cardiac health and disease progression. This review synthesizes the latest advancements in LACI research, elucidates its underlying pathophysiological mechanisms, and explores its expanding clinical applications as a pivotal tool for risk stratification, precision diagnostics, and personalized therapy in cardiovascular medicine.