AUTHOR=Wang Jin-jin , Yi Jin-ke , Zhou Li-rong , Chen Jun , Zhang Bin-qiang , Huang Hui-min , Wei Ying 

TITLE=A systematic review of the connection between serum uric acid levels and the risk of cardiovascular disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1577952

DOI=10.3389/fcvm.2025.1577952

ISSN=2297-055X

ABSTRACT=Serum uric acid (SUA) has emerged as a significant biomarker for cardiovascular disease (CVD) risk assessment, garnering increasing attention in recent years. As CVD remains a leading cause of global mortality, identifying effective biomarkers for risk stratification is of paramount importance. Current evidence indicates a strong association between elevated SUA levels and increased CVD risk. However, the precise mechanisms and confounding factors underlying this relationship remain unclear. This review examines the link between SUA and CVD, exploring potential biological pathways—including metabolic syndrome, inflammatory responses, and oxidative stress—that may mediate this association. By synthesizing existing literature, this article aims to provide insights for future research and clinical applications, ultimately enhancing the understanding of SUA's utility in CVD risk evaluation.