AUTHOR=Arango-Ibanez Juan Pablo , Cordoba-Melo Brayan Daniel , Barbosa Rengifo Mario Miguel , Tobar-Arteaga Jesika Daniela , Castro-Trujillo Maria Lucia , Herrera Cesar José , Quintana Da Silva Miguel Ángel , Buitrago Sandoval Andrés Felipe , Coronel Gilio María Lorena , Chon Long Freddy Pow , Cárdenas Aldaz Liliana , Valencia Andrea , Vesga-Reyes Carlos Enrique , Gómez-Mesa Juan Esteban 

TITLE=Two-year follow-up of patients with myocardial injury during acute COVID-19: insights from the CARDIO COVID 20–21 registry

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1584732

DOI=10.3389/fcvm.2025.1584732

ISSN=2297-055X

ABSTRACT=IntroductionCOVID-19 can cause Myocardial Injury (MI) during acute illness, which has been strongly associated with worse outcomes during hospitalization, however, more research is required on its effects on long-term outcomes, especially in underexplored regions in the literature such as Latin America.MethodsThis multicenter prospective cohort study follows up with patients with previous severe COVID-19 at a 2-year follow-up encounter. Comprehensive assessments were conducted including demographic data, clinical variables, psychiatric evaluations, and echocardiographic studies. Patients were stratified by the presence or absence of MI during their acute COVID-19 hospitalization. Statistical analyses included logistic regression and univariate comparisons.ResultsOf the 210 patients included, 53 (25%) had MI. Patients with MI were older, had a higher prevalence of comorbidities (e.g., hypertension, chronic kidney disease, atrial fibrillation), and were more likely to require intensive care unit admission, invasive mechanical ventilation, and vasopressor or inotropic support during acute COVID-19. Regarding long-term cardiovascular outcomes, no significant differences were observed in de novo cardiovascular disease, venous thromboembolism, or acute cardiovascular events. Patients with MI had greater odds of cardiopulmonary hospitalizations during follow-up (aOR 3.67, 95% CI 1.07–13.07, p = 0.037) after adjusting for age and sex.ConclusionPatients with prior MI during COVID-19 had a higher prevalence of comorbidities, poorer functional status, and increased odds of cardiopulmonary hospitalizations over a two-year follow-up evaluation compared to those without MI. Although prior studies suggest an association between MI and worse long-term outcomes, the evidence remains inconsistent. These findings emphasize the need for ongoing research to clarify how MI contributes to worsened long-term outcomes.