AUTHOR=Zhu Ping , Mei Dongmei , Yang Yan , Meng Defang , Hu Yaoyao , Wang Xiaoyan 

TITLE=Prevalence and determinants of multidimensional frailty in hospitalized older adults with coronary heart disease: a LASSO regression analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1588288

DOI=10.3389/fcvm.2025.1588288

ISSN=2297-055X

ABSTRACT=PurposeFrailty has increasingly been recognized as a multidimensional syndrome and is particularly prevalent among older adults with cardiovascular disease. This study aimed to assess the prevalence of multidimensional frailty and identify its key determinants in hospitalized elderly patients with coronary heart disease (CHD), with the goal of informing targeted strategies for early assessment and intervention.Patients and methodsA cross-sectional study was conducted involving 508 patients aged 60 years or older who were hospitalized with CHD at a tertiary hospital in China. Frailty was assessed using the Tilburg Frailty Indicator (TFI). Variables with statistical significance in univariate analysis were entered into a Selection Operator (LASSO) regression for selection. Least Absolute Shrinkage and LASSO regression and multivariate logistic regression analyses were performed to identify significant predictors.ResultsA total of 508 elderly patients with coronary heart disease who were hospitalized were included in the study, of whom 270 patients developed multidimensional frailty, resulting in an incidence rate of 53.15%. Variables with statistical significance in univariate analysis were entered into a LASSO regression for selection. Those retained by LASSO were then included in a multivariate logistic regression model. Multivariate analysis identified the following independent risk factors for multidimensional frailty: Age ≥ 75 years (OR = 2.821; 95% CI: 1.671–4.761); female (OR = 2.279; 95% CI: 1.426–3.643); insomnia (OR = 2.147; 95% CI: 1.374–3.354); depressive symptoms (OR = 4.233; 95% CI: 2.629–6.816). Conversely, higher scores on activities of daily living (ADL) (OR = 0.952; 95% CI: 0.921–0.984) and greater social support (OR = 0.935; 95% CI: 0.901–0.971) were protective against multidimensional frailty.ConclusionMultidimensional frailty is highly prevalent in hospitalized CHD patients and independently associated with psychosocial and functional factors. Early screening and integrated interventions targeting these determinants are essential to improve clinical outcomes.