AUTHOR=Duan Yuting , Liu Jia , Wang Shan , Luan Tongxiao , Zhou Jing , Cui Ziwei , Wang Aohua , Xu Mengru , Hu Song , Mao Yongjun 

TITLE=Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1616332

DOI=10.3389/fcvm.2025.1616332

ISSN=2297-055X

ABSTRACT=Coronary microvascular dysfunction (CMD) is a high-risk factor for numerous cardiovascular events, and there is an increasing focus on the diagnosis and treatment of CMD itself or its association with cardiovascular diseases. However, some evidences suggest potential associations between CMD and multiple extracardiac pathologies, such as cerebrovascular, renal, pulmonary, retinal, hepatic, immune system diseases, and cancer. A shared pathological mechanism may underlie these connections, yet the relationship between CMD and other organs and systemic diseases remains unclear. Therefore, this review comprehensively assesses the current evidence base for the interplay between CMD and a range of systemic diseases, highlighting the need for a more integrated diagnostic and therapeutic approach.